Hair Loss in Women — What the Latest Research Says About Minoxidil, PRP, and Spironolactone

Hair loss in women is more common than many realize—and its emotional toll can be significant. Thinning hair, widening parts, and overall hair volume loss can lead to decreased self-confidence and heightened anxiety. At Foxhall Dermatology, we understand that female hair loss is more than just a cosmetic concern—it’s a medical condition with effective, science-backed solutions.

Recent dermatologic literature has helped clarify which treatments offer the best results for different types of hair loss in women, including androgenetic alopecia, telogen effluvium, and hormonal hair thinning.

Emerging Treatment #1: Oral Minoxidil

Originally developed as a blood pressure medication, oral minoxidil is now a rising star in dermatology for treating female pattern hair loss. Compared to its topical counterpart, oral minoxidil is easier to use and often better tolerated, with excellent results shown in multiple studies.

Benefits of Oral Minoxidil:

• Daily low-dose tablet (typically 0.25–2.5 mg)

• Minimal side effects when monitored appropriately

• Noticeable thickening within 3–6 months

• Ideal for patients struggling with irritation with using topical products

Emerging Treatment #2: Platelet-Rich Plasma (PRP)

PRP therapy harnesses your body’s own growth factors to stimulate hair follicles. After a small blood draw, platelets are concentrated and injected into the scalp to promote hair regrowth and slow shedding.

PRP Treatment Protocol:

• 3 sessions spaced 4–6 weeks apart

• Maintenance every 6 months to one year

• Effective as a standalone treatment or combined with oral therapies

• Particularly helpful in early to moderate thinning

Hormonal Therapy: Spironolactone

For women with hormonally driven hair thinning, especially those with signs of polycystic ovary syndrome (PCOS) or excess androgens, spironolactone may be recommended. This oral medication blocks androgen receptors in the skin and scalp, helping reduce hair miniaturization over time.

Author

Stephen Suah, MD, MS Stephen Suah, MD, MS is a board-certified dermatologist and the owner of Foxhall Dermatology, a premier medical, surgical, and cosmetic dermatology practice in Washington, DC.